Neuroscience

Charles A. Dana Research Professor Raskin (Psychology and Neuroscience), Director; Neuroscience Coordinating Committee: Thomas S. Johnson Distinguished Professor of Biology Blackburn (Biology), Professor Dunlap (Biology), Brownell Professor of Philosophy Lloyd (Philosophy), Vernon Roosa Professor of Applied Science Masino (Psychology and Neuroscience); Associate Professors Blaise∙∙ (Engineering), Church (Chemistry and Neuroscience), and Guardiola-Diaz (Biology and Neuroscience); Assistant Professors Casserly∙∙ (Psychology) and Helt (Psychology and Neuroscience); Senior Lecturer and Laboratory Coordinator Swart; Visiting Assistant Professor Assaf

Neuroscience is a broad, multidisciplinary field concerned with the nervous system, its components, and functional activities, including behavior and consciousness. How do nerve cells function and develop, and how do they communicate? How do brains work, and how have they evolved? What is the nature of consciousness and the neural basis for behaviors and for human brain dysfunction? These are among the many questions being answered by contemporary neuroscience.

Neuroscience at Trinity involves faculty from the departments of biology, chemistry, engineering, philosophy, and psychology. The major is designed to give students a fundamental grounding in the sciences and the flexibility to direct their studies toward cellular/molecular, systems/behavioral, and clinical/cognitive aspects of neuroscience. A major in neuroscience can lead to a career in scientific research, the health professions, education, business, law, or government. The Trinity major also prepares students for further study in graduate school and medical school. Students who are considering a major in neuroscience should consult with the neuroscience director or a member of the Neuroscience Coordinating Committee as soon as possible to ensure the selection of an appropriate sequence of courses. Neuroscience students planning to attend graduate school for an advanced degree in any of the sciences are advised to take a course in statistics or statistical methods. Those who intend to enter a health-related profession should also consult with a member of the Health Professions Advising Committee.

The neuroscience major—The major requires 16 courses, including nine core courses and seven course credits from the list of electives. Electives must be selected from at least three different departments (biology, chemistry, engineering, neuroscience, philosophy, or psychology). No course grade of less than C- may be counted toward the major.

*HFPR 202. Health Care Research may substitute for NESC 425 provided the research is done in a neurological, neurosurgical, neuropsychiatric, or basic neuroscience laboratory setting. This substitution must be approved by the program director.

Breadth requirement—Electives must cover three departments (NESC, PSYC, BIOL, CHEM, ENGR, PHIL)

Depth option—In order to be designated as fulfilling a concentration in one area of neuroscience, students who choose to do so (in addition to fulfilling the breadth requirements above) must complete four electives as listed below. This will be indicated on their transcript (e.g., Neuroscience: Cellular/Molecular Concentration).

Four electives fulfill depth in one area:

To double major in neuroscience and another major, a maximum of three courses with a designation of 200 or above can be double-counted in both majors.

Honors in neuroscience—Honors in the major will be awarded to students who attain a B+ average in courses in the major at the 200 level and above (not including the research project) and who also demonstrate superior performance in a research project, culminating in a two-semester thesis, an oral proposal and final presentation, and a poster at the spring science symposium.

Courses at other institutions—Students who wish to earn major credit for course work at other institutions should submit to the director the name of the institution and the number, title, and catalog description of the course. This information must be submitted in writing before the work is initiated and formal permission must be granted before the courses can be credited toward the major at Trinity, following the usual procedures established by the Office of Study Away.

Study away—Neuroscience students who wish to study abroad should meet with their adviser and the program director in advance of the semester they intend to go abroad. Professor Guardiola-Diaz is currently the study-abroad adviser for the Neuroscience Program and can advise students regarding specific study-abroad options. There are many study-abroad locations that allow for course work in neuroscience as well as internship experiences. Students who wish to take a course for major credit while abroad must have this approved by the program director before going abroad.

Fall Term

[120. Nervous Connections]— Recent scientific research indicates that a worm has 302 neurons, snails have long-term memory, and elephants can hear through their feet. This course will draw on current research in neuroscience to explain why information about other animals is relevant to our lives. Selected readings, lectures and class discussions will provide a basic understanding of the human nervous system and how research on animal systems has yielded this knowledge. Laboratory exercises will introduce the students to nervous system anatomy and function through dissection and experimental techniques. A basic understanding of biology and chemistry will be helpful, but this course has no pre-requisites. First-year students are given preference. (NAT) (Enrollment limited)

[120L. Nervous Connections Laboratory]— This is an optional lab component that can be taken in conjunction with the Neuroscience 120 lecture. The laboratory exercises will introduce students to nervous system anatomy and function through dissection and experimental techniques. Concurrent enrollment in Neuroscience 120 Lecture is required. (0.25 course credit) (Enrollment limited)

301. Introduction to Neuroscience Methodology— A laboratory course that will introduce the student to current methods and techniques used in neuroscience research. The course consists of three-week rotations in the laboratories of staff members. Among the topics to be covered will be radioligand binding assays, neurochemical assays, electrophysiology, psychobiological techniques, experiments in perception, and methods in cognitive science. This course is normally taken in the junior year. (NAT) (Enrollment limited) –Assaf, Church, Guardiola-Diaz, Helt

[315. Functional Neuroanatomy]— This course provides an overview of the central, peripheral, and autonomic components of the human nervous system. Cellular, sub-cellular as well as organ-system aspects of nervous system functioning will be explored. Throughout the semester, basic scientific principles will be correlated with clinical case studies. References to the history of neurology will illustrate how our current concepts of nervous system functioning have evolved. The information covered in this course is critical for anyone interested in pursuing a career in either the basic or applied neurosciences. Prerequisite: C- or better in Neuroscience 201 or Psychology 261 (Enrollment limited)

388. Current Issues in Neuroscience— This half-credit course considers current neuroscience research on topics ranging from clinical research to molecular biology. Students will attend presentations by neuroscience researchers and read and discuss pertinent research literature prior to each presentation. Some special scheduling arrangements will be necessary for activities outside of the regular class meeting time. Prerequisite: Senior Neuroscience major, and a C- or better in Neuroscience 201, or permission of instructor. (0.5 course credit) (NAT) (Enrollment limited) –Masino

399. Independent Study— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 2 course credits) –Staff

419. Research in Neuroscience (Library)— Students will conduct library research projects under the direction of a faculty member. Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

425. Research in Neuroscience (Laboratory)— Students will conduct original laboratory research projects under the direction of an individual faculty member. Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

466. Teaching Assistantship— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

490. Research Assistantship— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

498. Senior Thesis Part 1— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for each semester of this yearlong thesis. (2 course credits are considered pending in the first semester; 2 course credits will be awarded for completion in the second semester). Prerequisite: permission of the instructor. (2 course credits) (WEB) –Staff

Graduate Courses

800. Graduate Seminar in Neuroscience— This half-credit seminar will cover current topics in neuroscience, including issues in research methodology, ethics in research and public policy issues. In addition, time will be spent reviewing the literature and methodology of the theses of enrolled students. The course will be structured like a journal club with students preparing a discussion of one to two articles each week to be shared. Many of the articles may be drawn from the background literature of the thesis topic. Students will also attend presentations by neuroscience researchers and read and discuss pertinent research literature prior to each presentation. (0.5 course credit) –Raskin

951. Independent Research— Under the guidance of a faculty member, graduate students may do an independent research project on a topic in neuroscience. Written approval of the graduate adviser and the program director are required. Contact the Office of Graduate Studies for the special approval form. (0.5 course credit) –Staff

953. Thesis Part 1— First credit of a two semester, two credit thesis in Neuroscience. Written approval of the graduate adviser and the program director are required. Contact the Office of Graduate Studies for the special approval form. –Staff

954. Thesis Part II— A continuation of NESC 953. Second credit of a two semester, two credit thesis in Neuroscience. Written approval of the graduate adviser and the program director are required. Contact the Office of Graduate Studies for the special approval form. –Staff

956. Thesis— Two credit thesis in Neuroscience. Written approval of the graduate adviser and the program director are required. Contact the Office of Graduate Studies for the special approval form. (2 course credits) –Staff

Courses Originating in Other Departments

Biology 120. Genes, Clones, and Biotechnology— View course description in department listing on p. 301. –Fleming

[Biology 140. Biological Systems]— View course description in department listing on p. 301.

[Biology 140L. Biological Systems - Lab]— View course description in department listing on p. 301. For this optional laboratory class the student must also enroll in the lecture section.

Biology 182. Evolution of Life— View course description in department listing on p. 301. –Blackburn, Dunlap, Fournier, Morrison, O’Donnell, Schneider

[Biology 211. Electron Microscopy]— View course description in department listing on p. 302. Prerequisite: C- or better in Biology 182 or Biology 183 and consent of instructor

Biology 224. Genetics— View course description in department listing on p. 302. Prerequisite: C- or better in Biology 182L and Biology 183L, or Permission of Instructor. –Fleming

Biology 224L. Genetics Laboratory— View course description in department listing on p. 302. Prerequisite: C- or better in BIOL 224-01, or concurrent enrollment. –Fleming

Biology 317. Biochemistry— View course description in department listing on p. 303. Prerequisite: C- or better in Chemistry 212L, Biology 182L and Biology 183L. –Guardiola-Diaz

Biology 319. Animal Physiology— View course description in department listing on p. 303. Prerequisite: C- or better in Biology 182L and Biology 183L, or Permission of Instructor. –Dunlap

[Biology 456. Biology of Communication]— View course description in department listing on p. 304. Prerequisite: C- or better in Biology 319L or Neuroscience 201.

[Biology 473. Sensory Biology]— View course description in department listing on p. 305. Prerequisite: C- or better in Biology 182, and Biology 183L, and Biology 319L or Neuroscience 201, or permission of instructor.

Engineering 311. Electrophysiology of the Central Nervous System— View course description in department listing on p. 409. –Blaise

[Psychology 255. Cognitive Psychology]— View course description in department listing on p. 775. Prerequisite: C- or better in Psychology 101.

[Psychology 255L. Cognitive Psychology Laboratory]— View course description in department listing on p. 775. Prerequisite: C- or better in Psychology 255, or concurrent enrollment.

Psychology 261. Brain and Behavior— View course description in department listing on p. 775. Prerequisite: C- or better in Psychology 101 or Biology 140 or Biology 181 or Biology 182 or Biology 183. –Raskin

Psychology 261L. Brain and Behavior Laboratory— View course description in department listing on p. 775. Prerequisite: C- or better in Psychology 261-01 or concurrent enrollment. –Ruskin

Psychology 265. Drugs and Behavior— View course description in department listing on p. 776. –Rosen

Psychology 302. Behavioral Neuroscience— View course description in department listing on p. 777. Prerequisite: C- or better in Psychology 261 or Neuroscience 201. –Masino

Psychology 334. Current Issues in Cognition— View course description in department listing on p. 777. Prerequisite: C- or better in Psychology 255 or Psychology 293, or permission of instructor –Casserly

Psychology 339. Developmental Psychopathology— View course description in department listing on p. 777. Prerequisite: C- or better in Psychology 261, or Psychology 270 or Psychology 273, or Psychology 295. –Helt

Psychology 364. Neuropsychopharmacology— View course description in department listing on p. 777. Prerequisite: C- or better in Psychology 261 or Neuroscience 201. –Gockel

[Psychology 434. Current Issues in Cognition]— View course description in department listing on p. 779. Prerequisite: C- or better in Psychology 255 or Psychology 293, or permission of instructor

[Psychology 464. Neuropsychopharmacology]— View course description in department listing on p. 779. Prerequisite: C- or better in Psychology 261 or Neuroscience 201.

Spring Term

[101. The Brain]— Recent developments in neuroscience have revolutionized our views of familiar human experiences such as locomotion, substance abuse, mental illness, sleep, and memorization. Through highly enjoyable and selected readings, presentations by visiting faculty, demonstrations and other activities, we will explore the foundations of this field as well as recent discoveries. The overall objective of this course is to provide students with a basic understanding of neuroscience, enabling them to make important decisions that may affect their lives. (NAT) (Enrollment limited)

120. Nervous Connections— Recent scientific research indicates that a worm has 302 neurons, snails have long-term memory, and elephants can hear through their feet. This course will draw on current research in neuroscience to explain why information about other animals is relevant to our lives. Selected readings, lectures and class discussions will provide a basic understanding of the human nervous system and how research on animal systems has yielded this knowledge. Laboratory exercises will introduce the students to nervous system anatomy and function through dissection and experimental techniques. A basic understanding of biology and chemistry will be helpful, but this course has no pre-requisites. First-year students are given preference. (NAT) (Enrollment limited) –Swart

201. Principles of Neuroscience— A team-taught introductory course in neuroscience that will examine the neuron and its biological interactions in animal nervous systems. Topics will include the anatomy, development, chemistry, and physiology of nervous systems. Prerequisite: C- or better in Biology 182 and 183. (NAT) (Enrollment limited) –Church, Swart

201L. Principles of Neuroscience Laboratory— A team-taught introductory course in neuroscience that will examine the neuron and its biological interactions in animal nervous systems. Topics will include the anatomy, development, chemistry, and physiology of nervous systems. Prerequisite: C- or better in Biology 183L or permission of instructor. (0.25 course credit) (Enrollment limited) –Swart

[320. Developmental Neuroscience]— This course will provide an overview of the developmental assembly of a complex nervous system. We will investigate the relations between developmental changes in the brain (morphology, neurochemistry, connectivity), and developmental changes in perceptual, cognitive, and social abilities (e.g., attention, executive function, empathy) throughout the lifespan. We will also address fundamental theoretical issues in the field of developmental neuroscience, such as the role of experience versus innate biological predisposition, the range of plasticity, and the functional degree of specialization in the brain. Part of this course will be devoted to gaining a better understanding of experimental methods utilized in the field of developmental neuroscience, in order to both critically analyze such studies, and, as a final paper, design your own study. Prerequisite: C- or better in Neuroscience 201 or Psychology 261 (NAT) (Enrollment limited)

[362. Neuroethology]— This course will explore the control of animal behavior by the nervous system from an evolutionary perspective. Topics to be covered include motor control (orientation, navigation, pursuit and escape behavior), communication systems (mate searching, territoriality, and social interactions), resource location and ingestion, circadian and other rhythmic behaviors and learning and memory. Examples will be drawn from a wide variety of vertebrate and invertebrate animals as appropriate to the topic. For select topics special attention will be paid to experimental design and data analysis. Text readings and selected primary research articles will guide discussion of each topic. In addition to exams and quizzes, students will write several short essays and one term paper during the course of the semester. Prerequisite: C- or better in Neuroscience 201 or Psychology 261 (WEB) (Enrollment limited)

388. Current Issues in Neuroscience— This half-credit course considers current neuroscience research on topics ranging from clinical research to molecular biology. Students will attend presentations by neuroscience researchers and read and discuss pertinent research literature prior to each presentation. Some special scheduling arrangements will be necessary for activities outside of the regular class meeting time. Prerequisite: Senior Neuroscience major, and a C- or better in Neuroscience 201, or permission of instructor. (0.5 course credit) (NAT) (Enrollment limited) –Masino

399. Independent Study— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 2 course credits) –Staff

401. Neurochemistry— An interdisciplinary course investigating the chemical processes involved in central nervous system functioning and communication. Emphasis will be placed on the chemical aspects of synthesis, metabolism, and release of neurotransmitters. The role of neurochemistry in behavioral and neurological disease states will be evaluated. Current research topics in this area will also be presented. Prerequisite: C- or better in Neuroscience 201, Chemistry 211, or permission of instructor. (WEB) (Enrollment limited) –Church

402. Cellular and Molecular Neurobiology— An advanced study of individual cells and small networks of cells in the nervous system. Specific topics include the development of neurons and glia, the cellular physiology of communication in the nervous system, and characterization of molecules responsible for unique properties of neurons. These cellular and molecular processes will be examined through lectures, student-led presentations, and laboratory experiments. Prerequisite: C- or better in Neuroscience 201, Biology 317L, or permission of instructor. (WEB) (Enrollment limited) –Guardiola-Diaz

419. Research in Neuroscience (Library)— Students will conduct library research projects under the direction of a faculty member. Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

425. Research in Neuroscience (Laboratory)— Students will conduct original laboratory research projects under the direction of an individual faculty member. Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

466. Teaching Assistantship— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

490. Research Assistantship— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for enrollment. (0.5 - 1 course credit) –Staff

[497. Senior Thesis]— (WEB)

499. Senior Thesis Part 2— Submission of the special registration form, available in the Registrar’s Office, and the approval of the instructor are required for each semester of this yearlong thesis. The research culminates in a thesis, an oral presentation, and a poster at the undergraduate Science Symposium. (2 course credits are considered pending in the first semester; 2 course credits will be awarded for completion in the second semester). Prerequisite: permission of the instructor. (2 course credits) (WEB) –Staff

Graduate Courses

[816. Neural Engineering]— This introductory course uses an integrative and cross-disciplinary approach to survey basic principles and modern theories and methods in several important areas of neural engineering. Course topics include: neural prosthetics, neural stimulation, neurophysiology, neural signal detection, and analysis and computational neural networks. The practicalities of the emerging technology of brain-computer interface as well as other research topics in neural engineering will be discussed. Students will also have the opportunity to perform hands-on computer simulation and modeling of neural circuits and systems.

[862. Neuroethology]— This course will explore the control of animal behavior by the nervous system from an evolutionary perspective. Topics to be covered include motor control (orientation, navigation, pursuit and escape behavior), communication systems (mate searching, territoriality, and social interactions), resource location and ingestion, circadian and other rhythmic behaviors and learning and memory. Examples will be drawn from a wide variety of vertebrate and invertebrate animals as appropriate to the topic. For select topics special attention will be paid to experimental design and data analysis. Text readings and selected primary research articles will guide discussion of each topic. In addition to exams and quizzes, students will write several short essays and one term paper during the course of the semester. (WEB)

[865. Cognitive and Social Neuroscience]— This course examines the way in which brain function influences mental processes and overt action. We will consider a range of cognitive and social functions, primarily from the perspective of neuroscience and draw on such related disciplines as cognitive psychology, social psychology, and computational analysis as needed. The functions to be reviewed include perception, attention, memory, thinking, emotional processing, group behavior, stereotyping and empathy. We will apply these to consider topics such as substance abuse, discrimination, child development, and mental illness. (WEB)

[874. Minds and Brains]— The neurosciences have made striking progress in recent years toward understanding the brains of animals and human beings. Through readings in philosophy and science we will consider what contribution this explosion of neuroscientific data can make to our understanding of the mind. (NAT)

[892. Human Neuropsychology]— The course will begin with a cursory review of basic neuroanatomy, brain organization and topography, and neurotransmitters and neurotransmitter conductive systems. Next, an in-depth examination of physiological and neurological manifestations of cognitive and psychopathological disorders as well as behavioral correlates of neuropathological and pathophysiological disturbances will follow. Finally, a survey of current diagnostic procedures and treatment approaches will be presented. All course material augmented with, and accentuated by, illustrative clinical case material. Students should anticipate that special scheduling arrangements will be required for activities outside of regular class sessions. (WEB)

Courses Originating in Other Departments

[Biology 120. Genes, Clones, and Biotechnology]— View course description in department listing on p. 305.

Biology 140. Biological Systems— View course description in department listing on p. 306. –Blackburn, Dunlap

Biology 183. Cellular Basis of Life— View course description in department listing on p. 307. Prerequisite: C- or better in Chemistry 111 or Permission of Instructor –Fleming, Foster, Fournier, Guardiola-Diaz, O’Donnell

Biology 211. Electron Microscopy— View course description in department listing on p. 307. Prerequisite: C- or better in Biology 182 or Biology 183 and consent of instructor –Blackburn

[Biology 227. Cell Biology]— View course description in department listing on p. 307. Prerequisite: C- or better in Biology 182L and Biology 183L, or Permission of Instructor.

[Biology 319. Animal Physiology]— View course description in department listing on p. 308. Prerequisite: C- or better in Biology 182L and Biology 183L, or Permission of Instructor.

Biology 473. Sensory Biology— View course description in department listing on p. 309. Prerequisite: C- or better in Biology 182, and Biology 183L, and Biology 319L or Neuroscience 201, or permission of instructor. –Dunlap

[Engineering 316. Neural Engineering]— View course description in department listing on p. 413. Open to all junior and senior life science and physical science majors.

Health Fellows Program 201. Topics in Health Care— Prerequisite: Acceptance into the Health Fellows Program. –Raskin

Health Fellows Program 202. Health Care Research— Prerequisite: Acceptance into the Health Fellows Program. –Draper, McGuire, Raskin

Philosophy 374. Minds and Brains— View course description in department listing on p. 725. –Lloyd

Psychology 255. Cognitive Psychology— View course description in department listing on p. 782. Prerequisite: C- or better in Psychology 101. –Casserly

Psychology 255L. Cognitive Psychology Laboratory— View course description in department listing on p. 782. Prerequisite: C- or better in Psychology 255, or concurrent enrollment. –Casserly

Psychology 261. Brain and Behavior— View course description in department listing on p. 782. Prerequisite: C- or better in Psychology 101 or Biology 140 or Biology 181 or Biology 182 or Biology 183. –Masino

Psychology 261L. Brain and Behavior Laboratory— View course description in department listing on p. 782. Prerequisite: C- or better in Psychology 261-01 or concurrent enrollment. –Masino

Psychology 293. Perception— View course description in department listing on p. 783. Prerequisite: C- or better in Psychology 101. –Nie

Psychology 293L. Perception Laboratory— View course description in department listing on p. 783. Prerequisite: C- or better in Psychology 293, or concurrent enrollment. –Staff

Psychology 339. Developmental Psychopathology— View course description in department listing on p. 784. Prerequisite: C- or better in Psychology 261, or Psychology 270 or Psychology 273, or Psychology 295. –Helt

[Psychology 365. Cognitive and Social Neuroscience]— View course description in department listing on p. 784. Prerequisite: C- or better in Psychology 255, 256, or 261, or Neuroscience 201.

Psychology 392. Human Neuropsychology— View course description in department listing on p. 785. Prerequisite: C- or better in Psychology 255, 256, or 261, or Neuroscience 201. –Raskin

[Psychology 464. Neuropsychopharmacology]— View course description in department listing on p. 786. Prerequisite: C- or better in Psychology 261 or Neuroscience 201.