Cascade Reactions Using Barbier Coupling Conditions

Rebecca Suflas ‘08

The stereoselectivity of indium promoted coupling reactions involving 1,3-dichloropropene was studied. The reaction was carried out using several different R-groups and solvents which were run under different conditions to determine how these changes would affect the product of the reaction. Each of the conditions yielded slightly different products and concentration of those products. Solvents used in this reaction were DMSO, NMF, THF, H₂O, and a 1:1 solution of DMSO/THF. The reactions utilized Barbier conditions under sonication.